Publications

Recent — Last 3 Years

Breithaupt L, Holsen LM, Ji C, Hu J, Petterway F, Rosa-Caldwell M, Nilsson IAK, Thomas JJ, Williams KA, Boutin R, Slattery M, Bulik CM, Arnold SE, Lawson EA, Misra M, Eddy KT. Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling. Biol Psychiatry Glob Open Sci. 2024 May 8;4(5):100332. doi: 10.1016j.bpsgos.2024.100332. PMID: 38989135; PMCID: PMC11233894.

Rosa-Caldwell ME, Pandeya S, Mortreux M, Rutkove SB. Predicting muscle function and mass with electrical impedance myography: a study in rat analogs of micro- and partial gravity. Accepted at Acta Astronautica July 10, 2024. Rosa-Caldwell ME, Breithaupt L, Kaiser UB, Garland E, Pinkham S, Hancock M, Jalkut SL, Rutkove SB. A Rodent Model of State-Specific Effects of Caloric Restriction and Weight Restoration in Anorexia Nervosa. Physiol Rep. 2024 June; 12(12): e16903. doi: 10.14814/phy2.16092

Issertine M, Rosa-Caldwell ME, Sung DM, Bouxsein ML, Rutkove SB, Mortreux M. Adaptation to full weight-bearing following disuse in rats: The impact of biological sex on musculoskeletal recovery. Physiol Rep. 2024 Feb;12(4):e15938. doi: 10.14814/phy2.15938. PMID: 38383049; PMCID: PMC10881285.

Schrems ER, Haynie WS, Perry RA Jr, Morena F, Cabrera AR, Rosa-Caldwell ME, Greene NP, Washington TA. Leucine Supplementation Exacerbates Morbidity in Male but Not Female Mice with Colorectal Cancer-Induced Cachexia. Nutrients. 2023 Oct 27;15(21):4570. doi: 10.3390/nu15214570. PMID: 37960223; PMCID: PMC10650865.

Rosa-Caldwell ME, Mortreux M, Wadhwa A, Kaiser UB, Sung DM, Bouxsein ML, Rutkove SB. Sex differences in muscle health in simulated micro- and partial-gravity environments in rats. Sports Med Health Sci. 2023 Sep 12;5(4):319-328. doi: 10.1016/j.smhs.2023.09.002. PMID: 38314043; PMCID: PMC10831389.

Cabrera AR, Deaver JW, Lim S, Morena da Silva F, Schrems ER, Saling LW, Tsitkanou S, Rosa-Caldwell ME, Wiggs MP, Washington TA, Greene NP. Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia. J Appl Physiol (1985). 2023 Sep 1;135(3):655-672. doi: 10.1152/japplphysiol.00196.2023. Epub 2023 Aug 3. PMID: 37535708.

Morena da Silva F, Lim S, Cabrera AR, Schrems ER, Jones RG, Rosa-Caldwell ME, Washington TA, Murach KA, Greene NP. The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males. BMC Genomics. 2023 Jul 4;24(1):374. doi: 10.1186/s12864-023-09462-7. PMID: 37403010; PMCID: PMC10318789.

Rosa-Caldwell ME, Mortreux M, Wadhwa A, Kaiser UB, Sung D-M, Bouxsein ML, Rutkove SB. Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats. J Appl Physiol (1985). 2023;134(6):1438-1449. doi:10.1152/japplphysiol.00023.2023

Washington TA, Schrem ER, Haynie WS, Rosa-Caldwell ME, Brown JL, Saling L, Lim S, Perry RA, Brown LA, Lee DE, Greene NP. Development of Skeletal Muscle Fibrosis in a Rodent Model of Cancer Cachexia. Cell Biochem Funct. 2023;41(4):478-489. doi:10.1002/cbf.3797

Rosa-Caldwell ME, Eddy KT, Rutkove SB, Breithaupt L. Anorexia nervosa and muscle health: A systematic review of our current understanding and future recommendations for study. Int J Eat Disord. 2022 Dec 18. doi: 10.1002/eat.23878. Epub ahead of print. PMID: 36529682.

Delfinis LJ, Bellissimo CA, Gandhi S, DiBenedetto SN, Garibotti MC, Thuhan AK, Tsitkanou S, Rosa-Caldwell ME, Rahman FA, Cheng AJ, Wiggs MP, Schlattner U, Quadrilatero J, Greene NP, Perry CG. Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress.  JCI Insight. 2022 Dec 22;7(24):e155147. doi: 10.1172/jci.insight.155147. PMID: 36346680.

Washington TA, Haynie WS, Schrems ER, Perry RA, Brown LA, Williams BM, Rosa-Caldwell ME, Lee DE, Brown JL. Effects of PGC1-α Overexpression on the Myogenic Response in Skeletal Muscle. Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration. 2022 July. doi: https://doi.org/10.1016/j.smhs.2022.06.005.

Morena da Silva F, Rosa-Caldwell ME, Schrems ER, Martinez L, Amos MG, Lim S, Cabrera AR, Brown JL, Washington TA, Greene NP. PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice. Appl Physiol Nutr Metab. 2022 Jun 14;. doi: 10.1139/apnm-2022-0086. [Epub ahead of print] PubMed PMID: 35700525.

Rosa-Caldwell ME, Poole KE, Seija A, Harris MP, Greene NP, Wooten JS. Exercise during weight-loss improves hepatic mitophagy. Sports Medicine and Health Science. 2022 April. doi: doi.org/10.1016/j.smhs.2022.04.003.

Lim S, Deaver JW, Rosa-Caldwell ME, Lee DE, Morena da Silva F, Cabrera AR, Schrems ER, Saling LW, Washington TA, Fluckey JD, Greene NP. Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner. Am J Physiol Endocrinol Metab. 2022 Mar 1;322(3):E278-E292. doi: 10.1152/ajpendo.00333.2021. Epub 2022 Jan 24. PubMed PMID: 35068192; PubMed Central PMCID: PMC8897019.

Atkins WC, Butts CL, Kelly MR, Troyanos C, Laursen RM, Duckett A, Emerson DM, Rosa-Caldwell ME, McDermott BP. Acute Kidney Injury Biomarkers and Hydration Outcomes at the Boston Marathon. Front Physiol. 2021;12:813554. doi: 10.3389/fphys.2021.813554. eCollection 2021. PubMed PMID: 35046841; PubMed Central PMCID: PMC8761943.

Lim S, Deaver JW, Rosa-Caldwell ME, Haynie WS, Morena da Silva F, Cabrera AR, Schrems ER, Saling LW, Jansen LT, Dunlap KR, Wiggs MP, Washington TA, Greene NP. Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice. J Appl Physiol (1985). 2022 Jan 1;132(1):58-72. doi: 10.1152/japplphysiol.00660.2021. Epub 2021 Nov 11. PubMed PMID: 34762526; PubMed Central PMCID: PMC8747017.

Rosa-Caldwell ME, Lim S, Haynie WS, Brown JL, Lee DE, Dunlap KR, Jansen LT, Washington TA, Wiggs MP, Greene NP. Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice. J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):2056-2068. doi: 10.1002/jcsm.12809. Epub 2021 Sep 29. PubMed PMID: 34585846; PubMed Central PMCID: PMC8718086.

Rosa-Caldwell ME, Mortreux M, Kaiser UB, Sung DM, Bouxsein ML, Dunlap KR, Greene NP, Rutkove SB. The oestrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss. Exp Physiol. 2021 Dec;106(12):2472-2488. doi: 10.1113/EP089962. Epub 2021 Oct 18. PubMed PMID: 34569104; PubMed Central PMCID: PMC8639792.

Deaver J, Schrems ER, Brown LA, Haynie WA, Perry, Jr,Richard,A, Rosa-Caldwell ME, Tedrowe MA, Greene NP, Washington TA. The Effect of Diet-Induced Obesity on Extracellular Matrix Remodeling during Skeletal Muscle Regeneration. Sports Medicine and Health Science. 2021 October. doi: https://doi.org/10.1016/j.smhs.2021.09.003.

Mortreux M, Rosa-Caldwell ME, Stiehl ID, Sung DM, Thomas NT, Fry CS, Rutkove SB. Hindlimb suspension in Wistar rats: Sex-based differences in muscle response. Physiol Rep. 2021 Oct;9(19):e15042. doi: 10.14814/phy2.15042. PubMed PMID: 34612585; PubMed Central PMCID: PMC8493566.

Rosa-Caldwell ME, Lim S, Haynie WA, Brown JL, Deaver JW, Morena Da Silva F, Jansen LT, Lee DE, Wiggs MP, Washington TA, Greene NP. Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy. J Cachexia Sarcopenia Muscle. 2021 Jun;12(3):717-730. doi: 10.1002/jcsm.12693. Epub 2021 Mar 5. PubMed PMID: 33675163; PubMed Central PMCID: PMC8200438.

Brown LA, Perry RA Jr, Haynie WS, Lee DE, Rosa-Caldwell ME, Brown JL, Greene NP, Wolchok JC, Washington TA. Moderators of skeletal muscle maintenance are compromised in sarcopenic obese mice. Mech Ageing Dev. 2021 Mar;194:111404. doi: 10.1016/j.mad.2020.111404. Epub 2020 Nov 26. PubMed PMID: 33249192.

Older — More than 3 Years

Rosa-Caldwell ME, Lim S, Haynie WS, Jansen LT, Westervelt LC, Amos MG, Washington TA, Greene NP. Altering aspects of mitochondrial quality to improve musculoskeletal outcomes in disuse atrophy. J Appl Physiol (1985). 2020 Dec 1;129(6):1290-1303. doi: 10.1152/japplphysiol.00407.2020. Epub 2020 Sep 17. PubMed PMID: 32940556; PubMed Central PMCID: PMC7792838.

Rosa-Caldwell ME, Benson CA, Lee DE, Brown JL, Washington TA, Greene NP, Wiggs MP. Mitochondrial Function and Protein Turnover in the Diaphragm are Altered in LLC Tumor Model of Cancer Cachexia. Int J Mol Sci. 2020 Oct 22;21(21). doi: 10.3390/ijms21217841. PubMed PMID: 33105841; PubMed Central PMCID: PMC7660065.

Mortreux M, Rosa-Caldwell ME. Approaching Gravity as a Continuum Using the Rat Partial Weight-Bearing Model. Life (Basel). 2020 Oct 8;10(10). doi: 10.3390/life10100235. Review. PubMed PMID: 33049988; PubMed Central PMCID: PMC7599661.

Lim S, Dunlap KR, Rosa-Caldwell ME, Haynie WS, Jansen LT, Washington TA, Greene NP. Comparative plasma proteomics in muscle atrophy during cancer-cachexia and disuse: The search for atrokines. Physiol Rep. 2020 Oct;8(19):e14608. doi: 10.14814/phy2.14608. PubMed PMID: 33063952; PubMed Central PMCID: PMC7556312.

Lee DE, Jacob BL, Rosa-Caldwell ME, Perry RA, Brown LA, Haynie WS, Washington TA, Wiggs MP, Greene NP. Cancer‐induced cardiac atrophy adversely affects myocardial redox state and mitochondrial oxidative characteristics. JCSM rapid communications. 2020 August. doi: https://doi.org/10.1002/rco2.18.

Rosa-Caldwell ME, Brown JL, Lee DE, Wiggs MP, Perry RA Jr, Haynie WS, Caldwell AR, Washington TA, Lo WJ, Greene NP. Hepatic alterations during the development and progression of cancer cachexia. Appl Physiol Nutr Metab. 2020 May;45(5):500-512. doi: 10.1139/apnm-2019-0407. Epub 2019 Oct 16. PubMed PMID: 31618604; PubMed Central PMCID: PMC7375466.

Rosa-Caldwell ME, Jansen LT, Lim S, Dunlap KR, Haynie WS, Washington TA, Greene NP. Neither autophagy nor exercise training mode affect exercise-induced beneficial adaptations in high fat-fed mice. Sports Medicine and Health Science. 2020 March; 2(1):44-53. doi: https://doi.org/10.1016/j.smhs.2020.03.003.

Rosa-Caldwell ME, Brown JL, Perry RA Jr, Shimkus KL, Shirazi-Fard Y, Brown LA, Hogan HA, Fluckey JD, Washington TA, Wiggs MP, Greene NP. Regulation of mitochondrial quality following repeated bouts of hindlimb unloading. Appl Physiol Nutr Metab. 2020 Mar;45(3):264-274. doi: 10.1139/apnm-2019-0218. Epub 2019 Jul 24. PubMed PMID: 31340136; PubMed Central PMCID: PMC7370318.

Rosa-Caldwell ME, Fix DK, Washington TA, Greene NP. Muscle alterations in the development and progression of cancer-induced muscle atrophy: a review. J Appl Physiol (1985). 2020 Jan 1;128(1):25-41. doi: 10.1152/japplphysiol.00622.2019. Epub 2019 Nov 14. Review. PubMed PMID: 31725360; PubMed Central PMCID: PMC6985812.

Rosa-Caldwell ME, Greene NP. Muscle metabolism and atrophy: let’s talk about sex. Biol Sex Differ. 2019 Aug 28;10(1):43. doi: 10.1186/s13293-019-0257-3. Review. PubMed PMID: 31462271; PubMed Central PMCID: PMC6714453.

Lee DE, Perry RA Jr, Brown JL, Rosa-Caldwell ME, Brown LA, Haynie WS, Rajaram N, Washington TA, Greene NP. Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice. Exp Gerontol. 2019 Jul 1;121:62-70. doi: 10.1016/j.exger.2019.03.009. Epub 2019 Mar 27. PubMed PMID: 30928679.

Blackwell TA, Cervenka I, Khatri B, Brown JL, Rosa-Caldwell ME, Lee DE, Perry RA Jr, Brown LA, Haynie WS, Wiggs MP, Bottje WG, Washington TA, Kong BC, Ruas JL, Greene NP. Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice. Physiol Genomics. 2018 Dec 1;50(12):1071-1082. doi: 10.1152/physiolgenomics.00061.2018. Epub 2018 Oct 5. PubMed PMID: 30289747; PubMed Central PMCID: PMC6337023.

Rosa-Caldwell ME, Todden C, Caldwell AR, Breithaupt LE. Confidence in eating disorder knowledge does not predict actual knowledge in collegiate female athletes. PeerJ. 2018;6:e5868. doi: 10.7717/peerj.5868. eCollection 2018. PubMed PMID: 30397554; PubMed Central PMCID: PMC6211262.

Brown JL, Lee DE, Rosa-Caldwell ME, Brown LA, Perry RA, Haynie WS, Huseman K, Sataranatarajan K, Van Remmen H, Washington TA, Wiggs MP, Greene NP. Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice. J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):987-1002. doi: 10.1002/jcsm.12354. Epub 2018 Oct 16. PubMed PMID: 30328290; PubMed Central PMCID: PMC6204589.

Perry RA Jr, Brown LA, Haynie WS, Brown JL, Rosa-Caldwell ME, Lee DE, Greene NP, Washington TA. Cardiac hypertrophy in sarcopenic obese C57BL/6J mice is independent of Akt/mTOR cellular signaling. Exp Gerontol. 2018 Oct 1;111:122-132. doi: 10.1016/j.exger.2018.06.023. Epub 2018 Jun 26. PubMed PMID: 29958999.

Caldwell AR, Gallagher KM, Harris BT, Rosa-Caldwell ME, Payne M, Daniels B, Ganio MS. Prolonged standing increases lower limb arterial stiffness. Eur J Appl Physiol. 2018 Oct;118(10):2249-2258. doi: 10.1007/s00421-018-3956-2. Epub 2018 Aug 3. PubMed PMID: 30076480.

Greene NP, Brown JL, Rosa-Caldwell ME, Lee DE, Blackwell TA, Washington TA. Skeletal Muscle Insulin Resistance as a Precursor to Diabetes: Beyond Glucoregulation. Curr Diabetes Rev. 2018;14(2):113-128. doi: 10.2174/1573399813666161122123636. Review. PubMed PMID: 27875947.

Brown JL, Rosa-Caldwell ME, Lee DE, Blackwell TA, Brown LA, Perry RA, Haynie WS, Hardee JP, Carson JA, Wiggs MP, Washington TA, Greene NP. Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):926-938. doi: 10.1002/jcsm.12232. Epub 2017 Aug 28. PubMed PMID: 28845591; PubMed Central PMCID: PMC5700433.

Rosa-Caldwell ME, Brown JL, Lee DE, Blackwell TA, Turner KW, Brown LA, Perry RA, Haynie WS, Washington TA, Greene NP. Autophagy activation, not peroxisome proliferator-activated receptor γ coactivator 1α, may mediate exercise-induced improvements in glucose handling during diet-induced obesity. Exp Physiol. 2017 Sep 1;102(9):1194-1207. doi: 10.1113/EP086406. Epub 2017 Jul 22. PubMed PMID: 28639297.

Brown JL, Rosa-Caldwell ME, Lee DE, Brown LA, Perry RA, Shimkus KL, Blackwell TA, Fluckey JD, Carson JA, Dridi S, Washington TA, Greene NP. PGC-1α4 gene expression is suppressed by the IL-6-MEK-ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury. Acta Physiol (Oxf). 2017 Jun;220(2):275-288. doi: 10.1111/apha.12826. Epub 2016 Nov 25. PubMed PMID: 27809412.

Lee DE, Brown JL, Rosa-Caldwell ME, Blackwell TA, Perry RA Jr, Brown LA, Khatri B, Seo D, Bottje WG, Washington TA, Wiggs MP, Kong BW, Greene NP. Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size. Physiol Genomics. 2017 May 1;49(5):253-260. doi: 10.1152/physiolgenomics.00006.2017. Epub 2017 Mar 24. PubMed PMID: 28341621.

Rosa-Caldwell ME, Lee DE, Brown JL, Brown LA, Perry RA Jr, Greene ES, Carvallo Chaigneau FR, Washington TA, Greene NP. Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice. Appl Physiol Nutr Metab. 2017 Feb;42(2):148-156. doi: 10.1139/apnm-2016-0280. Epub 2016 Oct 12. PubMed PMID: 28084795.

Lee DE, Brown JL, Rosa ME, Brown LA, Perry RA, Washington TA, Greene NP. Translational machinery of mitochondrial mRNA is promoted by physical activity in Western diet-induced obese mice. Acta Physiol (Oxf). 2016 Nov;218(3):167-177. doi: 10.1111/apha.12687. Epub 2016 Apr 25. PubMed PMID: 27061106.

Lee DE, Brown JL, Rosa ME, Brown LA, Perry RA Jr, Wiggs MP, Nilsson MI, Crouse SF, Fluckey JD, Washington TA, Greene NP. microRNA-16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion. J Cell Biochem. 2016 Aug;117(8):1775-87. doi: 10.1002/jcb.25476. Epub 2016 Jan 15. PubMed PMID: 26683117.

Greene NP, Lee DE, Brown JL, Rosa ME, Brown LA, Perry RA, Henry JN, Washington TA. Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice. Physiol Rep. 2015 Jul;3(7). doi: 10.14814/phy2.12470. PubMed PMID: 26177961; PubMed Central PMCID: PMC4552545. al PMCID: PMC4552545.